The trade-off is that 1mg and 2mg doses become very small volumes (10 and 20 units respectively), where measurement precision on cheaper syringes can be questionable
While the complete results of the study have not yet been published, an initial press release in 2024 indicated that tirzepatide reduced the relative risk for the composite endpoint (HF urgent visit or hospitalization, oral diuretic intensification, or cardiovascular death) by 38%
A+ experience
Theres going to be an explosion in the sheer number of compounds Kumar has found he can design bias into GLP-1 analogues by simply alkylating or trifluoroalkylating the N -terminal amino acid using an alkyl halide
Five studies 14,21,33,35,36 , were identified which evaluated the effect of GLP-1-based therapies on IMT using longitudinal designs
doi: 10.1016/j.molmet.2018.09.009 64 BerndtSIGustafssonSMgiRGannaAWheelerEFeitosaMFet al